Steven Kotler. Maria Treben. Paul Robinson. Instaread Summaries. Margaret Roberts.
Katherine Eban. John D. Andrew Weil. Dr Mark Sircus. Alison M. Paul Rutter. Greg De Moore.
Stephen M. Anna Lembke. Cynthia Kuhn. Graham Patrick. Laurence Brunton. Robert Tisserand. Dr Howard W Fisher.
Ben Goldacre. David Healy. Brigitte Mars. James Essinger. Adam Gottlieb. Patrick Gomella. William Campbell Douglass. Robert Whitaker. Alan R. Joann Zerwekh. Paula Manuel Bostwick. Simon Mills. Thomas Hale. Anton Bilton.
Mary Lou Michaelis. Thomas August. Gabrielle M. Conclusion Progress in the development of treatment options for CIC and IBS-C are being informed by the evolving understanding of the normal physiology of the gut and the complex pathophysiology of these disease states, coupled with improved definitions of clinically meaningful treatment outcomes. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli.
Nature ; : — 6.
Camilleri M. Guanylate cyclase C agonists: emerging gastrointestinal therapies and actions. Gastroenterology ; : — 7. Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate. Gastroenterology ; : — Guanylin: an endogenous activator of intestinal guanylate cyclase.
Prouroguanylin and proguanylin: purification from colon, structure, and modulation of bioactivity by proteases. Endocrinology ; : — Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.
Purchase Cyclic GMP: Synthesis, Metabolism, and Function, Volume 26 - 1st Edition. Print Book View all volumes in this series: Advances in Pharmacology. Cyclic GMP: Synthesis, Metabolism, and Function, Volume 26 (Advances in Pharmacology): Medicine & Health Science Books.
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. PLoS One ; 7 : e Cancer Res ; 60 : — 7. Pain ; : — Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol ; : — The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease.
Scand J Gastroenterol ; 50 : — N Engl J Med ; : — Obesity-induced colorectal cancer is driven by caloric silencing of the guanylin-GUCY2C paracrine signaling axis. Cancer Res ; 76 : — Gut ; 65 : — Am J Hum Genet ; 90 : — 9. Eur J Hum Genet ; 23 : — 2.
The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer. Cancer Epidemiol Biomarkers Prev ; 23 : — Peripheral mechanisms in irritable bowel syndrome. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis.
Clin Gastroenterol Hepatol ; 10 : — Bowel disorders.
Gastroenterol Johanson JF , Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther ; 25 : — Symptoms in chronic constipation. Dis Colon Rectum ; 40 : — 6. Efficacy and tolerability of guanylate cyclase-C agonists for irritable bowel syndrome with constipation and chronic idiopathic constipation: a systematic review and meta-analysis. Am J Gastroenterol The spectrum of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation: US survey assessing symptoms, care seeking, and disease burden.
Am J Gastroenterol ; : — 7. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology ; : 46 — Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses.
Dig Dis Sci ; 58 : — 6. Two randomized trials of linaclotide for chronic constipation. The evolution of stomach acidity and its relevance to the human microbiome. PLoS One ; 10 : e J Pharm Sci ; : — OpenUrl CrossRef. Inhibition of heat-stable toxin-induced intestinal salt and water secretion by a novel class of guanylyl cyclase C inhibitors. J Infect Dis ; : — Human enteroids as a model of upper small intestinal ion transport physiology and pathophysiology. Intestinal enteroids model guanylate cyclase C-dependent secretion induced by heat-stable enterotoxins.
Infect Immun ; 84 : — J Biol Chem ; : — Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.
Cell Tissue Res ; : — Expression of GC-C, a receptor-guanylate cyclase, and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine. Synthesis, biological activity and isomerism of guanylate cyclase C-activating peptides guanylin and uroguanylin. J Pept Res ; 50 : — Kuhn M. Molecular physiology of membrane guanylyl cyclase receptors. Physiol Rev ; 96 : — One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers.
J Pept Res ; 52 : — Side chain contributions to the interconversion of the topological isomers of guanylin-like peptides. J Pept Sci ; 11 : — Towards an understanding of the arginine-aspartate interaction. J Mol Biol ; : — Diarrheal disease constitutes one of the top two causes of mortality among young children in developing countries.
Optimization of quantitative PCR methods for enteropathogen detection. PLoS One ; 11 : e Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study MAL-ED. Lancet Glob Health ; 3 : e — e Two precursors of the heat-stable enterotoxin of Escherichia coli: evidence of extracellular processing. Mol Microbiol ; 4 : — Am J Physiol ; : C — C Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.
Eur J Pharmacol ; : — Murad is married and has five children. We are always looking for ways to improve customer experience on Elsevier. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.